Bronsted Acid-catalyzed Addition and Cyclization Reaction with Imine: From Aqueous Reaction to Enantioselective Reactions
نویسندگان
چکیده
منابع مشابه
Palladium-Catalyzed, Enantioselective Heine Reaction
Aziridines are important synthetic intermediates for the generation of nitrogen-containing molecules. N-Acylaziridines undergo rearrangement by ring expansion to produce oxazolines, a process known as the Heine reaction. The first catalytic, enantioselective Heine reaction is reported for meso-N-acylaziridines where a palladium(II)-diphosphine complex is employed. The highly enantioenriched oxa...
متن کاملAn enantioselective Brønsted acid catalyzed enamine Mannich reaction.
An enantioselective Brønsted acid catalyzed Mannich reaction between acetophenone derived enamines and N-Boc imines has been developed. Simple diol (S)-H(8)-BINOL has been identified as the optimal catalyst, to afford versatile beta-amino aryl ketones in good yield and enantiomeric excess.
متن کاملSynthesis of N-vinylindoles through copper catalyzed cyclization reaction of N-(2-alkynylphenyl)imine.
A copper(II)-catalyzed cyclization reaction of N-(2-alkynylphenyl)imine was developed. This strategy provided an effective procedure for the synthesis of substituted N-vinylindoles in moderate to good yields.
متن کاملEnantioselective synthesis of (-)-beta-santalol by a copper-catalyzed enynol cyclization-fragmentation reaction.
We report herein the first enantioselective, direct synthesis of the highly prized natural sandalwood odorant ( )-b-santalol (( )-1). The key step in the synthesis is an efficient copper-catalyzed rearrangement of an enynol. The increasing scarcity of East Indian sandalwood oil has motivated research chemists over the last 40 years to develop a synthesis of the most valuable component, ( )-b-sa...
متن کاملSquaramide-catalyzed enantioselective Friedel-Crafts reaction of indoles with imines.
Chiral squaramides are highly enantioselective catalysts for Friedel-Crafts reaction of indoles with N-tosyl imines, affording 3-indolyl methanamine products in 85-96% yields and 84-96% ees.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Synthetic Organic Chemistry, Japan
سال: 2005
ISSN: 0037-9980,1883-6526
DOI: 10.5059/yukigoseikyokaishi.63.1062